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Complex odontomas, hamartomas of aborted tooth development, mainly occur in posterior part of the mandible and rarely erupt into the oral cavity. The spontaneous eruption may be associated with pain, inflammation of adjacent soft tissues or recurrent infection.


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Asymmetric nanostructures such as nanobowls NBs can exhibit superior drug delivery performances owing to their concave structure and interior asymmetric cavities. Here, we present a facile one-step method for the fabrication of NB like structures from a mere single amino acid mimetic, N - 9-fluorenylmethoxycarbonyl - S -triphenylmethyl- L -cysteine following continuous-flow microfluidics enabled supramolecular self-assembly.

Erupted complex odontoma of the posterior maxilla: a rarity

Following fabrication, NBs were further infused into a vesicular shell consisting of the amino acid N - tert -butoxycarbonyl - S -triphenylmethyl- L -cysteine, carrying dual acid labile groups, the triphenylmethyl and the tert -butyloxycarbonyl groups. The NB infused core—shell like microstructures formed after the shell coating will now be addressed as NB-shells. Presence of pH-responsive shells bestowed the core—shell NB like structures with the ability to actively tune their surface pore opening and closing in response to environmental pH switch.

Additionally, when tested in an animal model of glioblastoma, the nanoformulations demonstrated ificantly higher retardation of tumour growth as compared to free Dox. Chibh, V. Katoch, A. Kour, F. Khanam, A. Yadav, M. Singh, G. Kundu, B. Prakash and J. Panda, Biomater. To request permission to reproduce material from this article, please go to the Copyright Clearance Center request .

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Request permissions. Continuous flow fabrication of Fmoc-cysteine based nanobowl infused core—shell like microstructures for pH switchable on-demand anti-cancer drug delivery S. Search articles by author Sonika Chibh.

Vibhav Katoch.

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Avneet Kour. Farheen Khanam. Amit Singh Yadav. Manish Singh.

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Gopal C. Bhanu Prakash. Jiban Jyoti Panda. Back to tab Fetching data from CrossRef. Back to tab .